Professor & Chair
136C Sudro Hall

Phone 701.231.7943
Fax 701.231-8333

Jagdish.Singh@ndsu.edu

Biography

Jagdish Singh is Professor and Chair of the Department of Pharmaceutical Sciences at NDSU College of Pharmacy, North Dakota and a Fellow of American Association of Pharmaceutical Scientists (AAPS) and Fellow, Association of Biotechnology and Pharmacy. Singh’s efforts focus on the mechanistic studies for developing and testing novel delivery technologies to deliver biotechnologically derived molecules (e.g., peptide, protein, and gene). US Department of Defense, National Institutes of Health, PhRMA Foundation, and AFPE have funded my research. Singh has published over 150 peer-reviewed papers and 270 abstracts.  

Singh has supervised over 30 graduate students and post-doctoral fellows, and over three dozen undergraduate and professional (Pharm.D.) research students. He has also served/ is serving on advisory committee of 25 graduate students in Pharmaceutical Sciences, Chemistry, Polymers and Coatings at NDSU.  Singh believes in a good graduate program and derives pleasure in mentoring large number of graduate students, seeing them maturing as scientists and excelling in their employment after graduation. He was instrumental in developing and implementing the combined Pharm.D./Ph.D. program at NDSU College of Pharmacy. 

The Department of Pharmaceutical Sciences at NDSU has witnessed significant growth in terms of research grants, publications, graduate education, interdisciplinary research and became the part of COBRE and INBRE from NIH during his ten years of leadership as a Department Chair. The department was ranked 9th in year 2009 in nation among the US schools and colleges of pharmacy based on number of Ph.D faculty receiving NIH funding. Under Singh’s leadership as department chair, National Research Council ranked the NDSU graduate program in pharmaceutical sciences 39th on the research based ranking and was above the University of Iowa and University of Kentucky. The program ranked # 1 in student support. Singh along with Dr. Peterson was  successful establishing a Center of Excellence for Economic Development (Center for Biopharmaceutical Research and Production).  In addition, Singh was part of two accreditations of our pharmacy program at NDSU, and currently serving to the executive team of the self-study for accreditation visit this year. 

Teaching Interests

I teach Pharmaceutical Dosage Forms and Delivery Systems to Pharm.D. students, and Advanced Biopharmaceutics to Ph.D. students at NDSU.

Research Interests

I conduct mechanistic studies for developing and testing novel delivery technologies to deliver biotechnologically derived molecules (e.g., peptide, protein, and gene) for the treatment of diabetes, cancer, and neurodegenerative diseases. The specific research interests are transdermal delivery of bioactive materials, conformational and chemical stabilization of proteins in delivery systems, delivery of therapeutic proteins and genes using microspheres and nanoparticles, nanomicelles, liposomes as well as synthesis and characterization of graft polymers for protein and gene delivery. 

Education

B.S. (Pharmacy, 1977), M.S. (Pharmacy, 1979), Ph.D. (Pharmaceutics, 1982):
BHU Institute of Technology, Varanasi.

Post-doctoral: University of Otago School of Pharmacy, Dunedin (1985-1988)
                       University of California, San Francisco (1992-1994). 

Professional Experience 

2002- current   Chair, Department of Pharmaceutical Sciences, 
                        NDSU, Fargo, ND
2001- current   Professor, Pharmaceutical Sciences, NDSU, Fargo, ND
1999-2001       Associate Professor, Department of Pharmaceutical Sciences,
                        NDSU, Fargo, ND
1994-1998       Assistant Professor, Department of Pharmaceutical Sciences, 
                        NDSU, Fargo, ND
1990-1992       Associate Professor (Reader), Department of Pharmaceutics, 
                        BHU Institute of Technology, Varanasi
1979-1989       Assistant/Sr. Assistant Professor (Lecturer/ Sr. Lecturer), 
                        Department of Pharmaceutics, 
                        BHU Institute of Technology, Varanasi 

Awards 

2009              Fellow, Association of Biotechnology and Pharmacy
2004              Fellow, AAPS (American Association of Pharmaceutical 
                     Scientists)
2001-02         Waldron Research Award in recognition of outstanding research 
                      achievement at NDSU
2001-02         Teacher of the Year Award, College of Pharmacy,NDSU
2000-01         Researcher of the Year Award, College of Pharmacy, NDSU
1999-00         Teacher of the Year Award, College of Pharmacy, 
                      NDSU                          
1998-99         Researcher of the Year Award, College of Pharmacy, NDSU
1997-98         Teacher of the Year Award, College of Pharmacy, NDSU 
1997-98         Preferred Professor by MortarBoard
1998-99         Preferred Professor by MortarBoard
1992-94         Visiting Postdoctoral Fellowship, University of California, 
                      San Francisco, CA
1985-88         University Grants Committee Postdoctoral Fellowship, 
                      New Zealand
1977-79         UGC Fellowship, Government of India
1973-77         UGC Scholarship, Government of India

Professional Memberships and Honors

• Member NIH Biomaterials, Delivery Systems and Nanotechnology IMST (13) Panel, June 2009, October 2009, March 2010, October 2010., October 2011
• Editor, International Union of Advanced Materials
• Chair, Implantables and Injectables session at 35th Annual Meeting & Exposition of the Controlled Release Society, July 12-16, New York, 2008.
• Member, History’s Trustee Committee, State Historical Society of North Dakota Foundation
  Member, United States Pharmacopeia, 1995-current
• Member, Editorial Board of Pharmaceutical Development and Technology
• Member, Editorial Board, Advanced Materials Letters
• Member, Editorial Board of Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
• Member, Editorial Board of Recent Patents in Drug Delivery and Formulation
• Member, Golden Key
• Member, Rho Chi (National Pharmacy Honor Society)
• Member, American Association for the Advancement of Science 
• Member, American Association of Colleges of Pharmacy
• Member, American Association of Pharmaceutical Scientists
• Member, Controlled Release Society, Inc.
• Member, Association of Pharmaceutical Teachers of India
• Member, Otago Pharmacological Association, Inc; 1986-88.
• Member, Otago Med. Sch. Res. Council, 1986-88.

Selected Publications (From a total list of 150 publications):

Biosensor Nanomaterials (Songjun Li, Jagdish Singh, He Li and I. Banerjee eds.), Wiley-VCH, 2011.

Mandke R, Singh J, Cationic nanomicelles for delivery of plasmids encoding interleukin-4 and interleukin-10 for prevention of autoimmune diabetes in mice. In press, Pharmaceutical Research, 2011.

Oak M, Singh J, Controlled delivery of basal level of insulin from chitosan-zinc-insulin complex loaded thermosensitive copolymer. Journal of Pharmaceutical Sciences, published online DOI 10.1002/JPS, p. 1-18, 2011.

Mandke R, Singh J, Effect of acyl chain length and unsaturation on physicochemical properties and transfection efficiency of N-acyl-substituted low-molecular-weight chitosan. Journal of Pharmaceutical Sciences, 1, 268-282, DOI 10.1002/JPS, 2011.

Khaled Al-Tahami, Mayura Oak, Rhishikesh Mandke and Jagdish Singh, Basal level insulin delivery: in vitro release, stability, biocompatibility and in vivo absorption from thermosensitive triblock copolymers. Journal of Pharmaceutical Sciences, 1-14, 2011.

Khaled Al-Tahami, Mayura Oak and Jagdish Singh, Controlled Delivery of insulin from phase sensitive polymeric systems: in vitro release, stability, biocompatibility, in vivo absorption and bioactivity of insulin. Journal of Pharmaceutical sciences, 100(6):2161-2171, 2011.

Sibao Chen, Daniel Pederson, Mayura Oak, and Jagdish Singh, In vivo absorption of steroidal hormones from smart polymer based delivery systems, Journal of Pharmaceutical Sciences, 99, 1-8, 2010.

Yu Tang and Jagdish Singh,  Thermosensitive Drug Delivery System of Salmon Calcitonin: In vitro Release, In vivo Absorption, Bioactivity and Therapeutic Efficacies. Pharmaceutical Research, 27(2), 272-284, 2010.

Chandrasekar Manoharan and Jagdish Singh, Evaluation of polyanhydride microspheres for basal insulin delivery: Effect of copolymer composition and zinc salt on encapsulation, in vitro release, stability, in vivo absorption and bioactivity in diabetic rats. Journal of Pharmaceutical Sciences, 98, 4237-4250, 2009.

Yu Tang and Jagdish Singh, Biodegradable and biocompatible thermosensitive polymer based injectable implant for controlled release of protein. International Journal of Pharmaceutics, 365, 34-43, 2009.

Ashwin Basarkar and Jagdish Singh, Poly(lactide-co-glycolide)-polymethacrylate nanoparticles for intramuscular delivery of plasmid encoding interleukin-10 to prevent autoimmune diabetes in mice. Pharmaceutical Research, 26 (1), 72-81, 2009.

Chandrasekar manoharam and Jagdish Singh, Insulin loaded PLGA microspheres: Effect of zinc salts on encapsulation, release, and stability, Journal of Pharmaceutical Sciences, 
(www.interscience.wiley.com), 98, 529-542, 2009. 

Yu Tang and Jagdish Singh,Controlled delivery of aspirin: Effect of aspirin on polymer degradation and in vitro release from PLGA based phase sensitive systems. International Journal of Pharmaceutics, 357, 119-125, 2008.

Sibao Chen and Jagdish Singh, Controlled release of growth hormone from thermosensitive triblock copolymer systems: In vitro and In vivo evaluation, International Journal of Pharmaceutics, 352, 58-65, 2008.

Chandrasekar Manoharan and Jagdish Singh, Effect of zinc on insulin stability in the primary emulsification of the microsphere preparation process, submitted to AAPS PharmSci, 2008.

S Singh, Dean C. Webster and J Singh, Thermosensitive polymers: synthesis, characterization and delivery of proteins, International Journal of Pharmaceutics, 341, 68-77, 2007.

Ashwin Basarkar, and Jagdish Singh, Preparation, characterization, cytotoxicity and transfection efficiency of poly (DL-lactide-co-glycolide) and poly (DL-lactic acid) cationic nanoparticles for controlled delivery of plasmid DNA. International Journal of Pharmaceutics, 343, 247-254, 2007.

Ashwin Basarkar and Jagdish Singh, Nanoparticulate systems for polynucleotide delivery. International Journal of Nanomedicine, 2, 353-360, 2007.

Khaled Al-Tahami and Jagdish Singh, Smart polymer based delivery systems for peptides and proteins. Recent Patents on Drug Delivery & Formulation,1, 65-71, 2007.

Ashwin Basarkar, Dilip Devineni, Ravi Palaniappan and Jagdish Singh, Preparation, characterization, cytotoxicity and transfection efficiency of poly (DL-lactide-co-glycolide) and poly (DL-lactic acid) cationic nanoparticles for controlled delivery of plasmid DNA. International Journal of Pharmaceutics, 343,247-254, 2007.

20. Babu Medi and Jagdish Singh, Skin targeted DNA vaccine delivery using electroporation in rabbits. II. Safety. International Journal of Pharmaceutics, 308 (1-2), 61-68, 2006.

Khaled AL-Tahami, Amanda Myer, and Jagdish Singh, Polylactic acid based injectable delivery systems for controlled release of a model protein,lysozyme. Pharmaceutical Development and Technology, 11, 79-86, 2006.

Babu Medi and Jagdish Singh, Prospects of vaccines for allergic and other immunological skin disorders. American Journal of Clinical Dermatology, 7 (3), 145-153, 2006.

S Singh and J Singh, Phase sensitive polymer-based controlled delivery systems of leuprolide acetate: in vitro release, biocompatibility, and in vivo absorption in rabbits, International Journal of Pharmaceutics, 328, 42-48, 2006.

S Chen, R. Pieper, DC Webster and J Singh, Triblock copolymers: Synthesis, characterization, and delivery of a model protein. International Journal of Pharmaceutics, 288 (2), 207-218, 2005.

Babu Medi and Jagdish Singh, In Vivo Non-Viral Cutaneous Gene Delivery using Electroporation. International Journal of Pharmaceutics, 294, 53-63, 2005.

S Chen and J Singh, Controlled release of testosterone from smart polymer solution based systems: In vitro evaluation. International Journal of Pharmaceutics, 295 (1-2), 183-190, 2005.

Sumeet K. Rastogi and Jagdish Singh, Iontophoretic enhancement of leuprolide acetate by fatty acids, limonene and depilatory lotions through porcine epidermis. Pharmaceutical Development and Technology, 9 (4), 341-348, 2004. 

Somnath Singh and Jagdish Singh, Dermal toxicity and microscopic alterations in vivo in rabbit by components of JP-8 jet fuel, Environmental Toxicology and Pharmacology, 16(3), 153-161, 2004.