Roberto Gomes, PhD

Image of Roberto Gomes

Assistant Professor
210B Sudro Hall 

Phone 701.231.1718
Fax 701.231.8333

Roberto.Gomes@ndsu.edu 

Education

2006-2011 - PhD in Science/Organic Chemistry, Institute of Chemistry, University of São Paulo, Brazil.
2002-2004 - B. S. in Chemistry, Ibirapuera University, Brazil.
2002-2004 - B. A. in Chemistry, Ibirapuera University, Brazil.

Teaching

PSCI 300, Pharmaceutical Organic Chemistry

Research Interests

  • Enantioselective synthesis
  • Development of novel small molecules, nucleotides and antibodies
  • Tumor-targeting strategy using enediones engineered with cytotoxic moiety/NIR probes to be used in cancer therapy. 
  • Development of new NIR fluorescent probe-therapeutic agent conjugate triggered by the acid pH of the environment of the tumor cell for the early diagnosis of pancreatic cancer and molecular drug discovery of Proteolysis Targeting Chimeric (PROTAC) based prototype.
  • Computational Chemistry to understand our results. 

Academic and Professional Appointments

2020-present – Assistant Professor of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND.
2019-2020 - Adjunct Professor, Department of Chemistry, University of Massachusetts Lowell, Lowell, MA.
2017-2020 - Postdoctoral Research Associate, Department of Chemistry and Chemical Biology, Harvard University.
2013-2016 - Assistant Professor, Faculty of Exact Sciences and Technologies, Federal University of Grande Dourados, Brazil.
2012-2013 - Postdoctoral Research Associate, Department of Chemistry, Federal University of Mato Grosso do Sul, Brazil.
2011 - Postdoctoral research Associate, Institute of Chemistry, University of São Paulo, Brazil
2008-2011 Assistant Professor, School of Pharmacy and School of Chemistry, Oswaldo Cruz College, Brazil. 

Awards and Honors 

2016 Mato Grosso do Sul Research Foundation (FUNDECT- 34784.513.5960.1702/2016), R$ 199,200.00
2015 Mato Grosso do Sul Research Foundation (FUNDECT- 59/300.362/2015), R$ 33,600.00
2014 CNPq Research’s Grant Awards (CNPq-459654/2014), R$ 30,000.00
2012 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES-022/2012), R$ 205,200,00
2008 Brazilian Chemistry Society award for best poster (doctoral category)
2006 CNPq Full Master Scholarship. 

Selected Publications 

  1. Gomes, R.S.; Corey, E.J.; A method for the Catalytic Enantioselective a-Azidation and a-Amination of Ketones from racemic a-bromo-ketones. J. Am. Chem. Soc., 2019, 141, 20058-20061.
  2. Gomes, R.S.; Jardim, G.A.M.; Carvalho, R.L.; Araujo, M.H.; da Silva Júnior, E.; Biomonitoring of Pharmacists and nurses at occupational risk from handling antineoplastic agents. Int. J. Pharm. Prac., 2019, 1-6.
  3. Santos, A.N.; Oliveira, R.J.; Gomes, R.S.; Freitas, C.A.F.; Beyond Copper-Catalysed Azide-Alkyne 1,3-dipolar Cycloaddition: Synthesis and mechanism insights. Tetrahedron, 2019, 75, 3697-3712, (Review article).
  4. Almeida, R.; Carvalho, R.; Nunes, M.; Gomes, R.S.; Pedrosa, L.; Simone, C.; Elumalai, G.; Geertsen, V.; Gravel, E. Doris, Eric; da Silva Júnior, E.; Carbon nanotube-ruthenium hybrids towards mild oxidation of sulfides to sulfones: Efficient synthesis of sulfonyl compounds with potential biological applications. Catal. Sci. Technol., 2019, 9, 2742-2748, Cover article, considered as a Hot Paper Article in 2019.
  5. Oliveira, R.J.; Pereira, F.; Pesarini, J.R.; Silveira, I.O.M.F.; Lima, D.P.; Beatriz, A.; Berno, C.R.; Monreal, A.C.D.; Antoniolli-Silva, A.C.M.B.; Gomes, R.S.; Assessment of the toxicogenic effects and cell death potential of the ester (Z)-methyl4-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-4-oxobut-2-anoate in combination with cisplatin, cyclophosphamide and doxorubicin. Gen. Mol. Biol., 2019, 3, 1-4.
  6. Yahagi, S.S.; Roveda, A.C.; Sobral, A.T.; Oliveira, I.P.; Caires, A.R.L.; Gomes, R.S.; Trindade, M.A.G.; An analytical evaluation of the synergistic effect on biodiesel oxidation stability promoted by binary and ternary blends containing multifunctional additives. Int. J. Anal. Chem., 2019, 1-10.
  7. Gomes, R.S.; Karla, M.; Corey, E.J.; Synthesis of Chiral Cyclic Alcohols from Chiral Epoxides by H or N Substitution with Frontside Displacement. Org. Lett., 2018, 20, 6310-6313.
  8. Silva Júnior, E.N.; Ackermann, L.; Liang, Y.; Jardim, G.A.M.; Gomes, R.S.; Weakly-coordinating N-oxide and carbonyl groups for metal-catalyzed C-H activation: The special case of A-ring functionalization. Chem. Comm., 2018, 54, 7398-7411, Cover article.
  9. Oliveira, E.J.T.; Pessatto, L.R.; Freitas, R. O.N.; Pelizaro, B.I.; Rabacow, A.P.M.; Vani, J.M.; Monreal, A.C.D.; Mantovani, M.S.; Azevedo, R.B.; Antoniolli-Silva, A.C.M.B.; Oliveira, R.J.; Gomes, R.S.; New Bis copper complex ((Z)-4-((4-chlorophenyl)amino)-4-oxobut-2-enoyl) oxy): Cytotoxicity in 4T1 cells and their toxicogenic potential in Swiss mice. Toxicol. Appl. Pharmacol., 2018, 356, 127-138.
  10.  Oliveira, R.J.; Leite, N.; Pesarini, J.R.; Oliveira, B.; Berno, C.R.; Araújo, F.H.; Silveira, I.O.M.F.; Nascimento, R.; Antoniolli-Silva, A.C.M.B.; Monreal, A.C.D.; Beatriz, A.; de Lima, D.P.; Gomes, R.S.; Assessment of genetic integrity, splenic phagocytosis and cell death potential of (Z)-4-((1,5-dimethyl-3-oxo-2-phenyl-2,3dihydro-1H-pyrazol-4-yl) amino)-4-oxobut-2-enoic acid and its effect when combined with commercial chemotherapeutics. Gen. Mol. Biol., 2018, 41, 154-166.
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