Pyroxasulfone (Zidua 85% DF) was applied at three application timings to evaluate effects on weed control in spring wheat compared with a fall application of glyphosate alone. There did not appear to be any difference in weed control due to timing of application. Control of green foxtail, lambsquarters, and kochia was fair to good with all rates applied, however, control was more consistent with rates of 2.25 and 2.5 oz/A of Zidua. There were no effects on wheat height and while there were differences in wheat yield, it was inconsistent, where in some Zidua treatments yield was less than in the glyphosate alone while in others there were no differences in yield.