Pyroxasulfone (Zidua SC) was applied at rates of 1.75 to 4.0 oz/A at three application timings in wheat. Application timings were at-planting preemergence, delayed preemergence (about a week after planting after wheat had germinated and coleoptiles were approximately 0.75 inches in length and had not emerged), and early postemergence (one-leaf wheat stage). Trials were conducted in 2019, 2020, and 2021 in order to evaluate over different environmental conditions. Trials were maintained weed free through postemergence application of grass and broadleaf herbicides applied to the entire trial. In all three years this trial was conducted there were no differences in wheat yield due to timing or rate of Zidua application. However, the Zidua label for spring wheat only allows for application of Zidua at the delayed preemergence or postemergence due to potential for injury to wheat.