Elisabetta Liverani

Assistant Professor

Faculty

Pharmaceutical Sciences

image of Elisabetta

Credentials

PhD

Areas of Study & Research

  • Platelet function and regulation during inflammation
  • The role of the P2Y12 signaling pathway in regulating platelet-lymphocyte interactions during sepsis
  • Sex-related differences in platelet activity and regulation in patients with sepsis
  • Sex-specific targeting of purinergic signaling pathways as novel drug-based therapies for the improved treatment of sepsis

Courses Taught

PSCI 301, Biochemistry and Molecular Biology for Pharmacists

Previous Work

2016–2020: Instructor, Sol Sherry Thrombosis Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA

2015–2016: Postdoctoral Research Scientist, Temple Lung Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA

2010–2015: Postdoctoral Fellow, Sol Sherry Thrombosis Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA

2008–2010: Postdoctoral Fellow, William Harvey Research Institute, Queen Mary University of London, UK

Awards & Honors

2018 Abstract Award, 47th Annual Philadelphia Workshop on Hemostasis, Phila., PA
2018 Editorial Board Member, Journal of International Immunopharmacology
2016 Scientist Developmental Grant, American Heart Association (2016-20), $308,000
2015 Travel Award, Society of Leukocyte Biology
2015 Jeanette Piperno Memorial Award, Temple University, Philadelphia, PA
2012 Abstract Achievement Award, American Society of Hematology

Education

  • 2003–2007: PhD in Pharmacology, Department of Applied Sciences, University of the West of England, Bristol, UK
  • 1995–2002: BS in Biological Sciences, University of Bologna, Italy

Publications

https://www.ncbi.nlm.nih.gov/myncbi/1LwjUqsk869kW/bibliography/public/

Selected Publications

Albayati S., Vemulapalli H., Tsygankov A.Y., and Liverani E. P2Y12 blockade results in altered interaction between platelets and regulatory T cells during sepsis. October 2020. J Leukoc Biol. 2020 Nov 26;. doi: 10.1002/JLB.3A0220-097R. [Epub ahead of print] PubMed PMID: 33242353

Liverani E., Tursi S.A., Cornwell W.D., Mondrinos M.J., Sun S., Buttaro B.A., Wolfson M.R., Rogers T.J. Tükel Ç, and Kilpatrick L.E. Targeted protein Kinase C-delta inhibition is organ-protective, enhances pathogen clearance, and improves survival in sepsis. FASEB J. 2020 Feb;34(2):2497-2510. doi: 10.1096/fj.201900897R.

Vemulapalli H., Albayati S., Tsygankov A.Y., and Liverani E. ADP Exerts P2Y12 -Dependent and P2Y12 -Independent Effects on Primary Human T Cell Responses to Stimulation. J Cell Commun Signal. 2020 Mar;14(1):111-126. doi: 10.1007/s12(079) 019-00540-8. Epub 2019 Dec 5. PubMed PMID: 31808055

Liverani E., Mondrinos M.J., Sun S., Kunapuli S.P., and Kilpatrick L.E. Role of Protein Kinase C-delta in regulating platelet activation and platelet-leukocyte interaction during sepsis. PLoS ONE 2018 3(4):e0195379. doi: 10.1371/journal.pone.0195379

Liverani E. Lung injury during LPS-induced inflammation occurs independently of the receptor P2Y1. Purinergic Signalling 2017 13(1):119-125

Liverani E., Rico M.C., Tsygankov A.Y., Kilpatrick L.E., and Kunapuli S.P. P2Y12 receptor modulates sepsis-induced inflammation. Arterioscler Thromb Vasc Biol 2016; 36: 961-71

Liverani E., Tsygankov A.Y., Kilpatrick L.E., and Kunapuli S.P. The role of P2Y12 receptor and activated platelets during inflammation. Curr Drug Target 2014; 15: 720-8

Liverani E., Rico M.C., Yaratha L., Tsygankov A.Y., Kilpatrick L.E., and Kunapuli S.P. LPS-induced systemic inflammation is more severe in P2Y12 null mice. J Leuko Biol 2014; 95: 313-23

Liverani E., Rico M.C., Garcia A.E. Kilpatrick L.E., and Kunapuli S.P. Prasugrel metabolites inhibit neutrophil functions. J Pharmacol Exp Ther 2013; 344: 231-43

Liverani E., Banerjee S., Roberts W., Naseem K.M., and Perretti M. Prednisolone exerts exquisite inhibitory properties on platelets functions. Biochem pharmacol 2012 15:1364-73